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   系統號碼964803
   書刊名Examination of the in vitro regenerative and neuroprotective potential of short chain fatty acid butyrate [electronic resource] /
   主要著者Lohmann, Clarissa Annabella.
   其他著者SpringerLink (Online service);臺灣學術電子書聯盟 (TAEBC)
   出版項Wiesbaden : Imprint: Springer, 2024.
   索書號QD305.F2L646 2024
   ISBN9783658463779
   標題Butyrates.
Neurology.
Neuroimmunology.
Oncology.
Neurological Disorders.
Diseases.
   電子資源https://doi.org/10.1007/978-3-658-46377-9
   叢書名Bestmasters,2625-3615;Bestmasters.2625-3615
   
    
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內容簡介Immune-mediated polyneuropathies stem from dysregulation of the immune system and affect a wide range of the population. Inflammatory diseases such as chronic inflammatory demyelinating polyneuropathy (CIDP) and Guillain-Barré syndrome (GBS) are the most common acute and chronic treatable immune-mediated polyneuropathies. The immune system mediates primarily demyelination but also neuronal degeneration through oxidative stress. As a result, patients suffer from hyporeflexia or areflexia accompanied with sensory and motor deficits as the disease progresses, which can lead to hospitalization and death. Over the years, nutrition and intestinal metabolism have become more relevant for the regulation of the immune system. In particular, short chain fatty acids (SCFA) have become the focus of attention. Currently, the best-studied SCFA is butyrate, produced by bacteria in the intestine along with propionate and acetate. Butyrate has already achieved promising results in areas such as oncology and immunology. Now, in the context of this master thesis, the question arises of the neuroprotective and neuroregenerative abilities of butyrate under oxidative stress. Die Autorin Clarissa Annabella Lohmann is PhD Student in Multiple Sclerosis Research in the Department of Neuropathology at the Georg August University Göttingen and the Fraunhofer ITMP - Translational Neuroinflammation and Automated Microscopy TNM.

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